Validation of Symptom Clusters
نویسندگان
چکیده
From February to September 2007, our study accrued 52 patients with bone metastases [29 men (56%), 23 women (44%); median age: 68.5 years (range: 39–87 years)] who were referred for palliative radiotherapy (RT). Prostate (31%), breast (29%), and lung (19%) were the most common primary cancer sites. Treatment arms ranged from single to multiple fractions, with most patients receiving a single 8-Gy fraction (77%) or 20 Gy in 5 fractions (21%). The most prevalent sites for RT were spine (42%), hips (17%), and pelvis (14%). Worst pain at the site of RT and functional interference scores were assessed using the Brief Pain Inventory (BPI), a multidimensional pain instrument that uses 11-point numeric rating scales. Patients provided their symptom severity scores on the BPI at baseline and at 4, 8, and 12 weeks post RT. At all time points, a principal component analysis with varimax rotation was performed on 8 items (worst pain and 7 functional interference items) to determine relationships between symptoms before and after RT for bone pain. Validation of symptom clusters in patients with metastatic bone pain
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